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Gut Liver. 2016 Jan;10(1):109-16. doi: 10.5009/gnl14345.

Clinical Implications of the Serum Apelin Level on Portal Hypertension and Prognosis of Liver Cirrhosis.

Lim YL1,2, Choi E3, Jang YO1,2, Cho YZ1,2, Kang YS1,2, Baik SK1,2, Kwon SO1, Kim MY1,2.

Author information

1
Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea.
2
Department of Cell Therapy and Tissue Engineering, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea.
3
Institute of Lifestyle Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.

Abstract

BACKGROUND/AIMS:

Levels of serum apelin (s-apelin), an endogenous ligand for angiotensin-like receptor 1, have been shown to be related to hepatic fibrosis and hemodynamic abnormalities in preclinical studies. We investigated the clinical implications of s-apelin as a noninvasive prognostic biomarker for chronic liver disease (CLD).

METHODS:

From January 2009 to December 2012, 215 CLD patients were enrolled and underwent clinical data collection, hepatic venous pressure gradient (HVPG) measurement, and liver biopsy. s-apelin was detected with a human total apelin enzyme-linked immunosorbent assay kit. All patients were prospectively observed during the median follow-up period of 23.0±12.9 months for decompensation and mortality.

RESULTS:

A total of 42 patients (19.5%) died during the follow-up period. s-apelin was significantly correlated with measurements of liver stiffness (R2=0.263, p<0.001) and collagen proportional area (R2=0.213, p<0.001) measured from liver biopsy tissue and HVPG (R2=0.356, p<0.001). In a multivariate analysis using a Cox regression hazard model, s-apelin was a weakly significant predictor of decompensation (hazard ratio [HR], 1.002; p<0.001) and mortality (HR, 1.003; p<0.001).

CONCLUSIONS:

s-apelin showed a significant relationship with CLD severity. However, its significance as a noninvasive biomarker for disease severity and prognosis was weak.

KEYWORDS:

Apelin; Biological markers; Liver cirrhosis; Portal hypertension; Prognosis

PMID:
25963087
PMCID:
PMC4694742
DOI:
10.5009/gnl14345
[Indexed for MEDLINE]
Free PMC Article

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