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Adv Mater. 2015 Jun 24;27(24):3620-5. doi: 10.1002/adma.201500417. Epub 2015 May 12.

Enzyme-Responsive Delivery of Multiple Proteins with Spatiotemporal Control.

Author information

1
Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, 420 Westwood Plaza, Los Angeles, CA, 90095, USA.
2
Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 710 Westwood Plaza, Los Angeles, CA, 90095, USA.

Abstract

Orchestrated biological materials such as enzymes and growth factors regulate the growth of tissues and organs. A chirality-controlled, single-protein technology is devised to tailor the spatiotemporally defined delivery of therapeutic proteins in response to natural enzymes present at wound sites. Sustained delivery of one protein and sequential delivery of two proteins are demonstrated for stroke and skin wound healing.

KEYWORDS:

chiral peptides; enzyme responsive; protein delivery; sequential release; wound healing

PMID:
25962336
PMCID:
PMC4633528
DOI:
10.1002/adma.201500417
[Indexed for MEDLINE]
Free PMC Article

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