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J Clin Invest. 2015 Jun;125(6):2220-7. doi: 10.1172/JCI78087. Epub 2015 May 11.

T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity.

Abstract

Systemic lupus erythematosus (SLE) is a prototype systemic autoimmune disease that results from a break in immune tolerance to self-antigens, leading to multi-organ destruction. Autoantibody deposition and inflammatory cell infiltration in target organs such as kidneys and brain lead to complications of this disease. Dysregulation of cellular and humoral immune response elements, along with organ-defined molecular aberrations, form the basis of SLE pathogenesis. Aberrant T lymphocyte activation due to signaling abnormalities, linked to defective gene transcription and altered cytokine production, are important contributors to SLE pathophysiology. A better understanding of signaling and gene regulation defects in SLE T cells will lead to the identification of specific novel molecular targets and predictive biomarkers for therapy.

PMID:
25961450
PMCID:
PMC4497749
DOI:
10.1172/JCI78087
[Indexed for MEDLINE]
Free PMC Article

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