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Evid Based Complement Alternat Med. 2015;2015:418023. doi: 10.1155/2015/418023. Epub 2015 Apr 16.

Protective Effect of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice.

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1
Department of Gastroenterology, Tangshan Gongren Hospital, Tangshan 06300, China.
2
Department of Intensive Care Unit, Hebei United University Affiliated Hospital, Tangshan 06300, China.
3
Department of Hepatobiliary Surgery, Tangshan Gongren Hospital, Tangshan 06300, China.

Abstract

We investigated the effects of Hericium erinaceus (HEM) on liver injury induced by acute alcohol administration in mice. Mice received ethanol (5 g/kg BW) by gavage every 12 hrs for a total of 3 doses. HEM (200 mg/kg BW) was gavage before ethanol administration. Subsequent serum alanine aminotransferase (ALT) level, aspartate aminotransaminase (AST) level, Maleic dialdehyde (MDA) level, hepatic total antioxidant status (TAOS), and activated nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) were determined by ELISA and immunohistochemistry, respectively. HEM administration markedly (P < 0.05) decreased serum ALT, AST, and MDA levels. The hepatic histopathological observations showed that HEM had a relatively significant role in mice model, which had alcoholic liver damage. In conclusion, we observed that HEM (200 mg/kg BW) supplementation could restrain the hepatic damage caused by acute alcohol exposure.

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