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J Magn Reson Imaging. 2015 Dec;42(6):1592-600. doi: 10.1002/jmri.24943. Epub 2015 May 9.

Reproducibility of quantitative susceptibility mapping in the brain at two field strengths from two vendors.

Author information

1
Department of Radiology, Weill Cornell Medical College, New York, New York, USA.

Abstract

PURPOSE:

To assess the reproducibility of brain quantitative susceptibility mapping (QSM) in healthy subjects and in patients with multiple sclerosis (MS) on 1.5 and 3T scanners from two vendors.

MATERIALS AND METHODS:

Ten healthy volunteers and 10 patients were scanned twice on a 3T scanner from one vendor. The healthy volunteers were also scanned on a 1.5T scanner from the same vendor and on a 3T scanner from a second vendor. Similar imaging parameters were used for all scans. QSM images were reconstructed using a recently developed nonlinear morphology-enabled dipole inversion (MEDI) algorithm with L1 regularization. Region-of-interest (ROI) measurements were obtained for 20 major brain structures. Reproducibility was evaluated with voxel-wise and ROI-based Bland-Altman plots and linear correlation analysis.

RESULTS:

ROI-based QSM measurements showed excellent correlation between all repeated scans (correlation coefficient R ≥ 0.97), with a mean difference of less than 1.24 ppb (healthy subjects) and 4.15 ppb (patients), and 95% limits of agreements of within -25.5 to 25.0 ppb (healthy subjects) and -35.8 to 27.6 ppb (patients). Voxel-based QSM measurements had a good correlation (0.64 ≤ R ≤ 0.88) and limits of agreements of -60 to 60 ppb or less.

CONCLUSION:

Brain QSM measurements have good interscanner and same-scanner reproducibility for healthy and MS subjects, respectively, on the systems evaluated in this study.

KEYWORDS:

brain; quantitative susceptibility mapping (QSM); reproducibility

PMID:
25960320
PMCID:
PMC4661140
DOI:
10.1002/jmri.24943
[Indexed for MEDLINE]
Free PMC Article

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