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Expert Rev Respir Med. 2015 Jun;9(3):269-75. doi: 10.1586/17476348.2015.1042458. Epub 2015 May 9.

Vitamin D supplementation: a comprehensive review on supplementation for tuberculosis prophylaxis.

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Barts and the London School of Medicine and Dentistry, Garrod Building, Turner Street, Greater London E1 2AD, UK.


Vitamin D plays a large role in the innate immune response against Mycobacterium tuberculosis (MTB) infection, activation and progression. Likewise, vitamin D deficiency is shown by evidence presented here to be a known risk factor for developing both MTB infection and active tuberculosis (TB). This comprehensive review discusses the evidence and remaining questions regarding vitamin D supplementation as a prophylactic measure in those who are at high risk of MTB infection and active TB. Vitamin D supplementation is routinely prescribed for osteoporosis prevention; yet, guidelines are lacking for its prescription for TB prevention, despite the adverse effects being rare. Policymakers are urged here to review the literature and provide urgent guidelines on vitamin D supplementation for TB prophylaxis.


Mycobacterium tuberculosis; prophylaxis; supplementation; tuberculosis; vitamin D

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