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Med Sci (Paris). 2015 Apr;31(4):423-31. doi: 10.1051/medsci/20153104017. Epub 2015 May 8.

[Strength and specificity of the CMBA screening platform for bioactive molecules discovery].

[Article in French]

Author information

1
Université Grenoble Alpes ; CEA-Direction des sciences du vivant, Institut de recherches en technologies et sciences pour le vivant, iRTSV-BGE-CMBA, CEA-Grenoble; Inserm UMRS_1038, 17, rue des Martyrs, 38054 Grenoble Cedex 9, France.
2
Université Grenoble Alpes ; CEA-Direction des sciences du vivant, Institut de recherches en technologies et sciences pour le vivant, BCI ; Inserm UMRS_1036, iRTSV-BCI-KIN, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France.

Abstract

Used as powerful chemical probes in Life science fundamental research, the application potential of new bioactive molecular entities includes but extends beyond their development as therapeutic drugs in pharmacology. In this review, we wish to point out the methodology of chemical libraries screening on living cells or purified proteins at the CMBA academic platform of Grenoble Alpes University, and strategies employed to further characterize the selected bioactive molecules by phenotypic profiling on human cells. Multiple application fields are concerned by the screening activity developed at CMBA with bioactive molecules previously selected for their potential as tools for fundamental research purpose, therapeutic candidates to treat cancer or infection, or promising compounds for production of bioenergy.

PMID:
25958761
DOI:
10.1051/medsci/20153104017
[Indexed for MEDLINE]
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