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Wei Sheng Yan Jiu. 2015 Jan;44(1):86-90.

[Study of DHA algal oil compound preparation on improving memory in mice].

[Article in Chinese]

Abstract

OBJECTIVE:

To investigate the effects of docosahexaenoic acid (DHA) algal oil compound preparation on improving memory in mice.

METHODS:

A total of 144 KM mice weighed 18 - 22 gram were classified into three groups randomized for the step - down test, passive avoidance test and water maze test respectively. For each test, we select 48 mice initially, then allocated the mice into 4 groups at random, each with 12 mice. According to the recommended dose of DHA algae oil soft capsule (600 mg/d) for human, each adult weight calculating on 60 kg meters, then we calibrate the dose to 50, 100 and 300 mg/kg BW (the equivalent doses of 5, 10 and 30 times to human) for three groups, respectively. The dose for intragastric injection administration is 10 ml/kg BW DHA algae oil, equivalent amount of edible vegetable oil for the control group, once per day for continuous 30 days. Just after the last lavage, we conduct the step - down test, passive avoidance test and water maze test respectively.

RESULTS:

DHA algal oil compound preparation has obvious effect on improving the reappearance ability of passive avoidance and the response of the avoiding darkness (P < 0.05). The indicators of water maze test were different statistically between DHA algal oil compound preparation groups and control group (P < 0.05).

CONCLUSION:

DHA algal oil compound preparation may play an important role in memory improvement in mice.

PMID:
25958644
[Indexed for MEDLINE]

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