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Radiat Prot Dosimetry. 2015 Sep;166(1-4):86-90. doi: 10.1093/rpd/ncv292. Epub 2015 May 9.

Energy dependence of the complexity of DNA damage induced by carbon ions.

Author information

1
Department of Physics, University of Pavia, Via Bassi 6, Pavia, Italy LENA, Laboratory of Applied Nuclear Energy, University of Pavia, Via Aselli 41, Pavia, Italy INFN National Institute of Nuclear Physics, Sezione di Pavia, Via Bassi 6, Pavia, Italy daniele.alloni@unipv.it.
2
Department of Physics, University of Pavia, Via Bassi 6, Pavia, Italy INFN National Institute of Nuclear Physics, Sezione di Pavia, Via Bassi 6, Pavia, Italy.
3
Institute of Radiation Protection, Helmholtz Zentrum München, Neuherberg 85764, Germany.
4
Department of Physics, University of Pavia, Via Bassi 6, Pavia, Italy INFN National Institute of Nuclear Physics, Sezione di Pavia, Via Bassi 6, Pavia, Italy Department of Oncology, Gray Institute for Radiation Oncology and Biology, Old Road Campus Research Building, Off Roosevelt Drive, Oxford OX3 7DQ, UK.

Abstract

To assess the complexity of DNA damage induced by carbon ions as a function of their energy and LET, 2-Gy irradiations by 100 keV u(-1)-400 MeV u(-1) carbon ions were investigated using the PARTRAC code. The total number of fragments and the yield of fragments of <30 bp were calculated. The authors found a particularly important contribution of DNA fragmentation in the range of <1 kbp for specific energies of <6 MeV u(-1). They also considered the effect of different specific energies with the same LET, i.e. before and after the Bragg peak. As a first step towards a full characterisation of secondary particle production from carbon ions interacting with tissue, a comparison between DNA-damage induction by primary carbon ions and alpha particles resulting from carbon break-up is presented, for specific energies of >1 MeV u(-1).

PMID:
25958411
DOI:
10.1093/rpd/ncv292
[Indexed for MEDLINE]

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