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Cell Stem Cell. 2015 May 7;16(5):465-76. doi: 10.1016/j.stem.2015.04.014.

Stem cell heterogeneity and plasticity in epithelia.

Author information

1
King's College London Centre for Stem Cells and Regenerative Medicine, 28(th) Floor, Tower Wing, Guy's Campus, Great Maze Pond, London SE1 9RT, UK.
2
King's College London Centre for Stem Cells and Regenerative Medicine, 28(th) Floor, Tower Wing, Guy's Campus, Great Maze Pond, London SE1 9RT, UK. Electronic address: fiona.watt@kcl.ac.uk.

Abstract

Epithelia cover the surfaces and line the cavities of the body. Recent studies have highlighted the existence of multiple stem cell compartments within individual epithelia that exhibit striking plasticity in response to tissue damage, transplantation, or tumor development. New knowledge about the composition of the epithelial niche and the transcription factor networks that maintain cell identity has provided new insights into the extrinsic and intrinsic regulation of stem cell behavior. In addition new in vitro tissue substitutes allow better integration of data from human and mouse models.

PMID:
25957902
DOI:
10.1016/j.stem.2015.04.014
[Indexed for MEDLINE]
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