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Cell Stem Cell. 2015 May 7;16(5):457-8. doi: 10.1016/j.stem.2015.04.012.

Converting a Problem into an Opportunity: mtDNA Heteroplasmy Shift.

Author information

1
Igenomix, Parc Cientific Valencia University, 46980 Paterna, Valencia, Spain.
2
Igenomix, Parc Cientific Valencia University, 46980 Paterna, Valencia, Spain; Fundación Instituto Valenciano de Infertilidad (FIVI), Department of Obstetrics & Gynecology, School of Medicine, Valencia University and Instituto Universitario IVI/INCLIVA, 46015 Valencia, Spain; Department of Obstetrics and Gynecology, Stanford University, Palo Alto, CA 94304, USA. Electronic address: carlos.simon@uv.es.

Abstract

The transmission of mitochondrial DNA (mtDNA) disease from a mother with a heteroplasmic mtDNA mutation to her children is unpredictable. In a recent issue of Cell, Reddy et al. (2015) present the potential for mitochondrial-targeted nucleases to remove mutated mtDNA through the induction of heteroplasmy shift in oocytes and zygotes.

PMID:
25957899
DOI:
10.1016/j.stem.2015.04.012
[Indexed for MEDLINE]
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