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FEBS Lett. 2015 Jun 22;589(14):1598-606. doi: 10.1016/j.febslet.2015.04.052. Epub 2015 May 13.

mRNA metabolism and neuronal disease.

Author information

1
Department of Biochemistry, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany; Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue, Box 70, New York, NY 10065, United States.
2
Department of Biochemistry, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany. Electronic address: utz.fischer@biozentrum.uni-wuerzburg.de.
3
Institute for Genetics, University of Cologne, Zülpicher Str. 47a, 50674 Köln, Germany.

Abstract

To serve as templates for translation eukaryotic mRNAs undergo an elaborate processing and maturation pathway. In eukaryotes this process comprises the synthesis of mRNA precursors, their processing and transport to the site of translation and eventually their decay. During the entire life cycle, mRNAs interact with distinct sets of trans-acting factors that determine their fate at any given phase of gene expression. Recent studies have shown that mutations in components acting in trans on mRNAs are frequent causes of a large variety of different human disorders. The etiology of most of these diseases is, however, only poorly understood, mostly because the consequences for mRNA-metabolism are unclear. Here we discuss three prominent genetic diseases that fall into this category, namely spinal muscular atrophy (SMA), retinitis pigmentosa (RP) and X-linked syndromic mental retardation (XLMR). Whereas SMA and RP can be directly linked to mRNA processing, XLMR results from mutations in the mRNA surveillance system. We discuss how defects in mRNA maturation and turnover might lead to the tissue specific defects seen in these diseases.

KEYWORDS:

Genetic disease; Post-transcriptional regulation of gene expression; Splicing; mRNA; mRNA turnover

PMID:
25957814
DOI:
10.1016/j.febslet.2015.04.052
[Indexed for MEDLINE]
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