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Cell. 2015 May 7;161(4):724-36. doi: 10.1016/j.cell.2015.04.033.

Genesis of chromatin and transcription dynamics in the origin of species.

Author information

1
Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, TheĀ Netherlands.
2
Theoretical Biology and Bioinformatics, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
3
Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, TheĀ Netherlands. Electronic address: h.t.m.timmers@umcutrecht.nl.

Abstract

Histone proteins compact and stabilize the genomes of Eukarya and Archaea. By forming nucleosome(-like) structures they restrict access of DNA-binding transcription regulators to cis-regulatory DNA elements. Dynamic competition between histones and transcription factors is facilitated by different classes of proteins including ATP-dependent remodeling enzymes that control assembly, access, and editing of chromatin. Here, we summarize the knowledge on dynamics underlying transcriptional regulation across the domains of life with a focus on ATP-dependent enzymes in chromatin structure or in TATA-binding protein activity. These insights suggest directions for future studies on the evolution of transcription regulation and chromatin dynamics.

PMID:
25957681
DOI:
10.1016/j.cell.2015.04.033
[Indexed for MEDLINE]
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