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J Biol Chem. 2015 Jul 10;290(28):17137-44. doi: 10.1074/jbc.R115.636472. Epub 2015 May 8.

Actin Mechanics and Fragmentation.

Author information

1
From the Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511 and enrique.delacruz@yale.edu.
2
the Institute for Biophysical Dynamics, James Franck Institute, and Department of Physics, University of Chicago, Chicago, Illinois 60637 gardel@uchicago.edu.

Abstract

Cell physiological processes require the regulation and coordination of both mechanical and dynamical properties of the actin cytoskeleton. Here we review recent advances in understanding the mechanical properties and stability of actin filaments and how these properties are manifested at larger (network) length scales. We discuss how forces can influence local biochemical interactions, resulting in the formation of mechanically sensitive dynamic steady states. Understanding the regulation of such force-activated chemistries and dynamic steady states reflects an important challenge for future work that will provide valuable insights as to how the actin cytoskeleton engenders mechanoresponsiveness of living cells.

KEYWORDS:

actin; biophysics; cell motility; cofilin; cytoskeleton; persistence length; rheology; severing; strain; stress

PMID:
25957404
PMCID:
PMC4498053
DOI:
10.1074/jbc.R115.636472
[Indexed for MEDLINE]
Free PMC Article

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