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Food Chem Toxicol. 2015 Aug;82:12-8. doi: 10.1016/j.fct.2015.04.025. Epub 2015 May 5.

Chemopreventive efficacy of menthol on carcinogen-induced cutaneous carcinoma through inhibition of inflammation and oxidative stress in mice.

Author information

1
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China.
2
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China; Jiangsu Key Laboratory for Pharmacolgy and Safety Evaluation of Chinese Materia Medica, Nanjing, Jiangsu 210023, China.
3
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China; Jiangsu Key Laboratory for Pharmacolgy and Safety Evaluation of Chinese Materia Medica, Nanjing, Jiangsu 210023, China. Electronic address: profyinlu@163.com.

Abstract

Inflammation and oxidative stress have been implicated in various pathological processes including skin tumorigenesis. Skin cancer is the most common form of cancer responsible for considerable morbidity and mortality, the treatment progress of which remains slow though. Therefore, chemoprevention and other strategies are being considered. Menthol has shown high anticancer activity against various human cancers, but its effect on skin cancer has never been evaluated. We herein investigated the chemopreventive potential of menthol against 9,10-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation, oxidative stress and skin carcinogenesis in female ICR mice. Pretreatment with menthol at various doses significantly suppressed tumor formation and growth, and markedly reduced tumor incidence and volume. Moreover, menthol inhibited TPA-induced skin hyperplasia and inflammation, and significantly suppressed the expression of cyclooxygenase-2 (COX-2). Furthermore, pretreatment with menthol inhibited the formation of reactive oxygen species and affected the activities of a battery of antioxidant enzymes in the skin. The expressions of NF-κB, Erk and p38 were down-regulated by menthol administration. Thus, inflammation and oxidative stress collectively played a crucial role in the chemopreventive efficacy of menthol on the murine skin tumorigenesis.

KEYWORDS:

COX-2; Cancer chemoprevention; Inflammation; Menthol; Oxidative stress; Skin tumorigenesis

PMID:
25956868
DOI:
10.1016/j.fct.2015.04.025
[Indexed for MEDLINE]

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