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DNA Repair (Amst). 2015 Aug;32:165-171. doi: 10.1016/j.dnarep.2015.04.028. Epub 2015 May 1.

BRCA1: Beyond double-strand break repair.

Author information

1
Stanford University School of Medicine, Department of Medicine/Oncology, 269 Campus Drive, Stanford, CA 93405, USA. Electronic address: ealli@stanford.edu.
2
Stanford University School of Medicine, Department of Medicine/Oncology, 269 Campus Drive, Stanford, CA 93405, USA; Stanford University School of Medicine, Department of Genetics, 269 Campus Drive, Stanford, CA 93405, USA. Electronic address: jmf@stanford.edu.

Abstract

Since its discovery, the BRCA1 tumor suppressor has been shown to play a role in multiple DNA damage response pathways. Here, we will review the involvement of BRCA1 in base-excision DNA repair and highlight its clinical implications.

KEYWORDS:

BRCA1; Base-excision repair

PMID:
25956865
DOI:
10.1016/j.dnarep.2015.04.028
[Indexed for MEDLINE]

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