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Arch Womens Ment Health. 2016 Apr;19(2):409-13. doi: 10.1007/s00737-015-0532-1. Epub 2015 May 10.

Transdermal estradiol treatment during breastfeeding: maternal and infant serum concentrations.

Author information

1
Asher Center for the Study and Treatment of Depressive Disorders, Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, 676. N. St. Clair Street, Suite 1000, Chicago, IL, 60611, USA. emily.pinheiro@northwestern.edu.
2
Department of Pediatrics, Division of General Academic Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
3
Asher Center for the Study and Treatment of Depressive Disorders, Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, 676. N. St. Clair Street, Suite 1000, Chicago, IL, 60611, USA.

Abstract

We examined estradiol (E2) and estrone (E1) concentrations in breastfeeding mother-infant dyads. The mothers had postpartum depression and were participants in a randomized clinical trial with three treatments (transdermal E2, sertraline, and placebo). Neither infant E1 and E2 concentrations nor infant growth differed across the treatments. Transdermal E2 administration of 50 to 200 mcg/day for breastfeeding women did not affect infant E1 or E2 concentrations or infant growth.

KEYWORDS:

Breastfeeding; Estradiol; Infant; Major depressive disorder; Postpartum depression

PMID:
25956588
PMCID:
PMC4641053
DOI:
10.1007/s00737-015-0532-1
[Indexed for MEDLINE]
Free PMC Article

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