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Clin Implant Dent Relat Res. 2016 Aug;18(4):725-34. doi: 10.1111/cid.12353. Epub 2015 May 7.

Implant Prosthetic Rehabilitation in Controlled HIV-Positive Patients: A Prospective Longitudinal Study with 1-Year Follow-Up.

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Dental School, Vita-Salute University and IRCCS San Raffaele, Milan, Italy.
Faculty of Psychology, UniSR Social Lab (Research Methods), Vita-Salute San Raffaele University, Milan, Italy.
Dental School, University of Brescia, Brescia, Italy.
Dental School, Vita-Salute San Raffaele University, Milan, Italy.



The clinical trial aimed to evaluate the survival of implant-prosthetic rehabilitation in controlled HIV-positive patients.


This mono-centric study included HIV patients with a stable disease, requiring implant rehabilitation, with good oral hygiene. Each patient received at least one dental implant. After 90 days in the upper jaw and 60 days in the lower jaw, the appropriate prosthesis was delivered.Primary outcome measures were prosthetic failures, implant failures, peri-implant marginal bone level changes (MBLCs), and biological complications (peri-implantitis, pus, pain, paresthesia). Data were recorded before the intervention (T0), and 6 (T1) and 12 months (T2) after.


Implants were positioned in 68 patients (22 females and 46 males; 194 implants). Two dropouts occurred for exacerbation of the disease before the sixth month of follow-up, and 66 patients (with 190 implants) completed the study. Forty-eight patients (70.6%) received total removable dentures; 11 patients (16.2%) received partial prosthesis, and nine patients (13.2%) received single elements.Implant failure occurred in nine patients (15 fixtures out of 190). These were early implant failures due to primary infection (five fixtures out of 190: 2.6%) and to peri-implantitis (10 fixtures out of 190: 5.2%). Prosthetic failure was registered in two patients (3% of patients) due to the loss of all the fixtures. Pus and pain were observed in 4/7 and 3/7 patients with peri-implantitis, respectively. No fractures of fixtures or paresthesia were registered. At T2, the mean peri-implant MBLC was -1.19 ± 0.87 mm.


Within its limitations, the study showed that in a well-controlled population of HIV patients implant rehabilitation can be a suitable options with results slightly worse to those obtained in normal population. A higher incidence of peri implant infections in the first six months was present pointing to the need of a proper protocol for infection control.


AIDS; HIV; implant; implant survival; implantology; osseointegration; peri-implantitis

[Indexed for MEDLINE]

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