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Int J Endocrinol. 2015;2015:908575. doi: 10.1155/2015/908575. Epub 2015 Apr 14.

Strain US Elastography for the Characterization of Thyroid Nodules: Advantages and Limitation.

Author information

1
Department of Radiology, Anatomopathology and Oncology, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
2
Venizelio Regional General Hospital of Heraklion, Leoforos Knosou, 714 09 Iraklio, Greece.
3
Department of Surgical Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.
4
University of Tirana, Rruga Arben Broci, Tirana, Albania.
5
University Hospital of Pavia, Viale Camillo Golgi 19, 27100 Pavia, Italy.
6
Department of Medicine and Health Sciences, University of Molise, Contrada Tappino, 86100 Campobasso, Italy.
7
Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.

Abstract

Thyroid nodules, with their high prevalence in the general population, represent a diagnostic challenge for clinicians. Ultrasound (US), although absolutely reliable in detecting thyroid nodules, is still not accurate enough to differentiate them into benign and malignant. A promising novel modality, US elastography, has been introduced in order to further increase US accuracy. The purpose of this review article is to assess the thyroid application of US strain elastography, also known as real-time elastography or quasistatic elastography. We provide a presentation of the technique, and of up-to-date literature, analyzing the most prominent results reported for thyroid nodules differentiation. The practical advantages and limitations of strain elastography are extensively discussed herein.

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