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World J Gastroenterol. 2015 May 7;21(17):5359-71. doi: 10.3748/wjg.v21.i17.5359.

Fecal microbiota transplantation as novel therapy in gastroenterology: A systematic review.

Author information

1
Noortje G Rossen, Elisabeth M de Vries, Geert R D'Haens, Cyriel Y Ponsioen, Department of Gastroenterology and Hepatology, Academic Medical Center Amsterdam, 1105 AZ Amsterdam, The Netherlands.

Abstract

AIM:

To study the clinical efficacy and safety of Fecal microbiota transplantation (FMT). We systematically reviewed FMT used as clinical therapy.

METHODS:

We searched MEDLINE, EMBASE, the Cochrane Library and Conference proceedings from inception to July, 2013. Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category, on an intention-to-treat basis.

RESULTS:

We included 45 studies; 34 on Clostridium difficile-infection (CDI), 7 on inflammatory bowel disease, 1 on metabolic syndrome, 1 on constipation, 1 on pouchitis and 1 on irritable bowel syndrome (IBS). In CDI 90% resolution of diarrhea in 33 case series (n = 867) was reported, and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial (RCT) (n = 16). In ulcerative colitis (UC) remission rates of 0% to 68% were found (n = 106). In Crohn's disease (CD) (n = 6), no benefit was observed. In IBS, 70% improvement of symptoms was found (n = 13). 100% Reversal of symptoms was observed in constipation (n = 3). In pouchitis, none of the patients (n = 8) achieved remission. One RCT showed significant improvement of insulin sensitivity in metabolic syndrome (n = 10). Serious adverse events were rare.

CONCLUSION:

FMT is highly effective in CDI, and holds promise in UC. As for CD, chronic constipation, pouchitis and IBS data are too limited to draw conclusions. FMT increases insulin sensitivity in metabolic syndrome.

KEYWORDS:

Clostridium difficile infection; Fecal microbiota transplantation; Inflammatory bowel disease; Metabolic syndrome; Microbiota

PMID:
25954111
PMCID:
PMC4419078
DOI:
10.3748/wjg.v21.i17.5359
[Indexed for MEDLINE]
Free PMC Article

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