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Genome Announc. 2015 May 7;3(3). pii: e00403-15. doi: 10.1128/genomeA.00403-15.

Draft Genome Sequence of Mycobacterium tuberculosis Strain E186hv of Beijing B0/W Lineage with Reduced Virulence.

Author information

1
Laboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Moscow, Russia.
2
Ural Research Institute for Phthisiopulmonology, Ekaterinburg, Russia.
3
Department of Molecular Microbiology & Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
4
Laboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Moscow, Russia valerid@vigg.ru.

Abstract

We report a draft genome sequence of Mycobacterium tuberculosis strain E186hv, belonging to the Beijing B0/W lineage and isolated from a patient from Kurgan, Russia. This clinical isolate showed a reduced virulence phenotype unusual for this lineage and resistance to isoniazid, rifampin, ethambutol, pyrazinamide, and ofloxacin. We analyzed single nucleotide polymorphisms (SNPs) associated with virulence.

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