Abstract
The mechanism of anti-ulcer effect of Solcoseryl, an extract from calf blood, was studied. Solcoseryl (10 ml/kg, i. v.) increased basal and chemically reduced potential difference of the gastric mucosa in rats. Solcoseryl (1-10 ml/kg, i.v.) also increased gastric mucosal blood flow and gastroduodenal HCO3- secretion. These results indicate that Solcoseryl has a mucosal protective effect which may contribute to the mechanism of its anti-ulcer effect.
MeSH terms
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Actihaemyl / pharmacology*
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Animals
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Anti-Ulcer Agents / pharmacology*
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Aspirin / pharmacology
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Bicarbonates / metabolism
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Biomechanical Phenomena
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Duodenum / metabolism
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Electrophysiology
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Ethanol / pharmacology
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Gastric Mucosa / blood supply
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Gastric Mucosa / metabolism
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Gastric Mucosa / physiology
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Indomethacin / pharmacology
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Intestinal Mucosa / metabolism
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Male
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Rats
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Rats, Inbred Strains
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Regional Blood Flow / drug effects
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Tissue Extracts / pharmacology*
Substances
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Anti-Ulcer Agents
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Bicarbonates
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Tissue Extracts
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Actihaemyl
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Ethanol
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Aspirin
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Indomethacin