OARSI Clinical Trials Recommendations: Hand imaging in clinical trials in osteoarthritis

D J Hunter; N Arden; F Cicuttini; M D Crema; B Dardzinski; J Duryea; A Guermazi; I K Haugen; M Kloppenburg; E Maheu; C G Miller; J Martel-Pelletier; R E Ochoa-Albíztegui; J-P Pelletier; C Peterfy; F Roemer; G E Gold

doi:10.1016/j.joca.2015.03.003

OARSI Clinical Trials Recommendations: Hand imaging in clinical trials in osteoarthritis

Osteoarthritis Cartilage. 2015 May;23(5):732-46. doi: 10.1016/j.joca.2015.03.003.

Authors

D J Hunter¹, N Arden², F Cicuttini³, M D Crema⁴, B Dardzinski⁵, J Duryea⁶, A Guermazi⁷, I K Haugen⁸, M Kloppenburg⁹, E Maheu¹⁰, C G Miller¹¹, J Martel-Pelletier¹², R E Ochoa-Albíztegui¹³, J-P Pelletier¹², C Peterfy¹⁴, F Roemer¹⁵, G E Gold¹⁶

Affiliations

¹ Institute of Bone and Joint Research, Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, NSW, Australia. Electronic address: David.Hunter@sydney.edu.au.
² NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, UK; Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis, University of Oxford, UK.
³ School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne 3004, Australia.
⁴ Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, United States; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, SP, Brazil.
⁵ Department of Radiology & Radiological Sciences, Uniformed Services University of Health Sciences, Bethesda, MD, USA.
⁶ Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, USA.
⁷ Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, United States.
⁸ Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
⁹ Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, 2300 RC, Leiden, Netherlands.
¹⁰ Department of Rheumatology, Hôpital Saint-Antoine, AP-HP, Paris, France.
¹¹ Bioclinica, Newtown, PA, USA.
¹² Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.
¹³ Department of Radiology, The American British Cowdray Medical Center IAP, Mexico.
¹⁴ Spire Sciences, Inc., Boca Raton, FL, USA.
¹⁵ Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, United States; Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany.
¹⁶ Stanford University, Departments of Radiology, Bioengineering, and Orthopedic Surgery, USA.

PMID: 25952345
DOI: 10.1016/j.joca.2015.03.003

Abstract

Tremendous advances have occurred in our understanding of the pathogenesis of hand osteoarthritis (OA) and these are beginning to be applied to trials targeted at modification of the disease course. The purpose of this expert opinion, consensus driven exercise is to provide detail on how one might use and apply hand imaging assessments in disease modifying clinical trials. It includes information on acquisition methods/techniques (including guidance on positioning for radiography, sequence/protocol recommendations/hardware for MRI); commonly encountered problems (including positioning, hardware and coil failures, sequences artifacts); quality assurance/control procedures; measurement methods; measurement performance (reliability, responsiveness, validity); recommendations for trials; and research recommendations.

Keywords: Guidelines; Hand osteoarthritis; Imaging.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Cartilage, Articular / pathology*
Clinical Trials as Topic / standards*
Disease Progression
Hand Joints / pathology*
Humans
Magnetic Resonance Imaging / standards*
Osteoarthritis / diagnosis*
Practice Guidelines as Topic / standards*

Grants and funding

AR062068/AR/NIAMS NIH HHS/United States