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J Am Soc Nephrol. 2015 Sep;26(9):2081-95. doi: 10.1681/ASN.2014121192. Epub 2015 May 7.

The Future of Polycystic Kidney Disease Research--As Seen By the 12 Kaplan Awardees.

Author information

1
National Institute of Health and Medical Research, Laboratory of Inherited Kidney Diseases, Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, and The Department of Genetics, Necker Hospital, Paris, France;
2
The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas; ayu@kumc.edu JCALVET@kumc.edu.
3
Kidney Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland;
4
The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas;
5
Center for Translational Science, Children's National Health System, Washington, DC;
6
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota;
7
Howard Hughes Medical Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts;
8
Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands;
9
Departments of Internal Medicine and Genetics, Yale University School of Medicine, New Haven, Connecticut;
10
Renal Division, Department of Medicine, University Medical Center Freiburg, Freiburg, Germany; and.
11
Harvard Center for Polycystic Kidney Disease Research, Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Abstract

Polycystic kidney disease (PKD) is one of the most common life-threatening genetic diseases. Jared J. Grantham, M.D., has done more than any other individual to promote PKD research around the world. However, despite decades of investigation there is still no approved therapy for PKD in the United States. In May 2014, the University of Kansas Medical Center hosted a symposium in Kansas City honoring the occasion of Dr. Grantham's retirement and invited all the awardees of the Lillian Jean Kaplan International Prize for Advancement in the Understanding of Polycystic Kidney Disease to participate in a forward-thinking and interactive forum focused on future directions and innovations in PKD research. This article summarizes the contributions of the 12 Kaplan awardees and their vision for the future of PKD research.

KEYWORDS:

genetic renal disease; genetics and development; polycystic kidney disease

PMID:
25952256
PMCID:
PMC4552123
DOI:
10.1681/ASN.2014121192
[Indexed for MEDLINE]
Free PMC Article

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