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Clin Chim Acta. 2015 Jun 15;446:263-6. doi: 10.1016/j.cca.2015.04.036. Epub 2015 May 4.

Clinical correlation between a point-of-care testing system and laboratory automation for lipid profile.

Author information

1
Hospital Israelita Albert Einstein, São Paulo, SP, Brazil; Federal University of São Paulo - UNIFESP, São Paulo, Brazil. Electronic address: carlos.ferreira@einstein.br.
2
Federal University of São Paulo - UNIFESP, São Paulo, Brazil; University of Santo Amaro - UNISA, São Paulo, Brazil.
3
Federal University of Paraná, Curitiba, Brazil.
4
ZIVD, LLC, Metuchen, NJ, USA.
5
Federal University of São Paulo - UNIFESP, São Paulo, Brazil.

Abstract

BACKGROUND:

We evaluated the clinical correlation between the CardioChek PA analyzer and a clinical laboratory reference method to use for screening program purposes.

METHODS:

Fasting blood samples were collected on 516 patients (age 20-85 y). One venous sample was collected using a serum tube for the evaluation on a COBAS reference analyzer. A second venous sample was collected in a lithium heparin tube and was evaluated on the CardioChek PA analyzer (CCPA venous). A fingerstick sample (CCPA fingerstick) was evaluated only on the CardioChek PA analyzer. Linear regression analyses were performed for each measured analyte, total cholesterol, HDL-cholesterol and triglycerides.

RESULTS:

The correlation between the CCPA fingerstick and CCPA venous was extremely high for HDL-C and triglycerides, and good for total cholesterol. Our results demonstrated a good clinical agreement for total cholesterol, HDL-C and triglycerides between 97.7% and 94.6% in the comparison of the CCPA to the reference analyzer.

CONCLUSIONS:

We identified the pre-analytic phase as an important step to guarantee the quality of results and indicate that the CardioChek PA is a reliable lipid point-of-care testing system that can be used for the application of clinical screening anywhere.

KEYWORDS:

CardioChek PA; Cardiovascular diseases; Point-of-care testing

PMID:
25952166
DOI:
10.1016/j.cca.2015.04.036
[Indexed for MEDLINE]

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