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Graefes Arch Clin Exp Ophthalmol. 2016 Feb;254(2):243-52. doi: 10.1007/s00417-015-3039-6. Epub 2015 May 8.

Retinal vessel oxygen saturation and vessel diameter in retinitis pigmentosa at various ages.

Author information

1
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University,, 54 Xianlie Road, Guangzhou, Guangdong, 510060, China.
2
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University,, 54 Xianlie Road, Guangzhou, Guangdong, 510060, China. gaoqy@mail.sysu.edu.cn.

Abstract

PURPOSE:

This study was conducted to determine whether oxygen saturation and retinal blood vessel diameter are affected by retinitis pigmentosa (RP) at various ages.

METHODS:

Relative oxygen saturation was measured in retinal blood vessels in 68 RP patients and 136 normal subjects using the Oxymap T1 retinal oximeter. Subjects were divided into two age groups: Group A (20-40 years) and Group B (> 40 years). One randomly selected eye of each subject was used for statistical analysis. Student's t tests were used to analyze the mean saturation and diameter of retinal arterioles and venules and arteriovenous differences between RP and normal subjects in the two age groups. A Spearman test was used to analyze the correlation of mean saturation of retinal arterioles (AS) and arteriovenous differences (AVS) with visual acuity, disease duration, and electroretinogram (ERG) b-wave amplitude in patients with RP.

RESULTS:

AS was significantly higher in patients with RP (105.5 ± 9.4 %) than in normal subjects (94.5 ± 4.4 %, p = 0.000) in Group A, while in Group B, AS was significantly lower in RP patients (86.8 ± 10.3 %) than in healthy subjects (96.0 ± 4.8 %, p = 0.000). Vessel diameter was smaller in RP patients than in normal subjects. AS and AVS showed a negative correlation with disease duration and a tendency toward positive correlation with ERG b-wave in patients with RP.

CONCLUSIONS:

The shifting characteristics of retinal vessel oxygen saturation suggest that the pathological mechanism of retinal oxygen metabolic disorder differs by age in patients with RP.

KEYWORDS:

Hypoxia; Oximetry; Oxygen saturation; Retina; Retinitis pigmentosa

PMID:
25952041
DOI:
10.1007/s00417-015-3039-6
[Indexed for MEDLINE]

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