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J Clin Periodontol. 2015 Jun;42(6):547-56. doi: 10.1111/jcpe.12413. Epub 2015 May 30.

Deproteinized bovine bone in association with guided tissue regeneration or enamel matrix derivatives procedures in aggressive periodontitis patients: a 1-year retrospective study.

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Department of Periodontology and Oral Implants, Tel Aviv University, Tel Aviv, Israel.
Currently in Private Practice, Herzliya, Israel.
Currently in Private Practice, Haifa, Israel.
Currently in Private Practice, Tel Aviv, Israel.



To retrospectively evaluate and compare two regenerative periodontal procedures in young individuals with aggressive periodontitis (AgP).


Thirty-two patients aged 14-25 years (mean ± SD 19.3 ± 5.7) were diagnosed as having AgP with multiple intra-bony defects (IBDs) and treated by one of two regenerative modalities of periodontal therapy: guided tissue regeneration (GTR) using deproteinized bone xenograft (DBX) particles and a resorbable membrane (the GTR group), or an application of enamel matrix derivatives (EMD) combined with DBX (the EMD/DBX group). Periodic monitoring of treated sites included recording of probing depth (PD), clinical attachment level (CAL) and gingival recession. Pre-treatment and 1-year post-operative findings were statistically analysed within and between groups.


The PD and CAL values decreased significantly with time, but not those between study groups. The mean pre-treatment and 1-year post-treatment PDs of the IBDs of the GTR group (n = 16; sites = 67) were 8.93 ± 1.14 mm and 3.58 ± 0.50 mm, respectively, and the mean CALs were 9.03 ± 1.03 mm and 4.16 ± 0.53 mm respectively. The mean PDs of the EMD/DBX group (n = 16; sites = 73) were 8.77 ± 1.04 mm and 3.61 ± 0.36 mm, respectively, and the mean CALS were 8.79 ± 1.04 mm and 3.77 ± 0.22 mm respectively (p < 0.001 for all).


Surgical treatment of AgP patients by either GTR or by application of EMD/DBX yielded similarly successful clinical results at 1-year post-treatment.


Aggressive periodontitis; deproteinized bovine bone (Bio-Oss®); enamel matrix derivatives (Emdogain®); guided tissue regeneration; periodontal regeneration

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