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Oncoimmunology. 2015 Feb 3;4(1):e985942. eCollection 2015 Jan.

Anti-oxidant capacity and anti-tumor T cell function: A direct correlation.

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Department of Surgery; Medical University of South Carolina ; Charleston, SC USA.
Oral Health Sciences; Medical University of South Carolina ; Charleston, SC USA.


Improving persistence and sustained function of effector CD8+ T cell response is key for achieving significant tumor control in adoptive T cell immunotherapy protocols. Our recent report shows that high anti-oxidant property is central to potent anti-tumor effector T cells, and directly correlates to CD62Lhi central memory, low glycolytic and low mitochondrial membrane potential phenotype, all of which may be linked and contribute to better tumor control.


adoptive immunotherapy, melanoma, Thiols, T cell

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