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Oncoimmunology. 2015 Feb 3;4(1):e985942. eCollection 2015 Jan.

Anti-oxidant capacity and anti-tumor T cell function: A direct correlation.

Author information

1
Department of Surgery; Medical University of South Carolina ; Charleston, SC USA.
2
Oral Health Sciences; Medical University of South Carolina ; Charleston, SC USA.

Abstract

Improving persistence and sustained function of effector CD8+ T cell response is key for achieving significant tumor control in adoptive T cell immunotherapy protocols. Our recent report shows that high anti-oxidant property is central to potent anti-tumor effector T cells, and directly correlates to CD62Lhi central memory, low glycolytic and low mitochondrial membrane potential phenotype, all of which may be linked and contribute to better tumor control.

KEYWORDS:

adoptive immunotherapy, melanoma, Thiols, T cell

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