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Oxid Med Cell Longev. 2015;2015:313021. doi: 10.1155/2015/313021. Epub 2015 Apr 8.

The protective effect of lipoic acid on selected cardiovascular diseases caused by age-related oxidative stress.

Author information

1
Department of Applied Pharmacy, Department of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.
2
Department of Cardiovascular Physiology, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland.

Abstract

Oxidative stress is considered to be the primary cause of many cardiovascular diseases, including endothelial dysfunction in atherosclerosis and ischemic heart disease, hypertension, and heart failure. Oxidative stress increases during the aging process, resulting in either increased reactive oxygen species (ROS) production or decreased antioxidant defense. The increase in the incidence of cardiovascular disease is directly related to age. Aging is also associated with oxidative stress, which in turn leads to accelerated cellular senescence and organ dysfunction. Antioxidants may help lower the incidence of some pathologies of cardiovascular diseases and have antiaging properties. Lipoic acid (LA) is a natural antioxidant which is believed to have a beneficial effect on oxidative stress parameters in relation to diseases of the cardiovascular system.

PMID:
25949771
PMCID:
PMC4407629
DOI:
10.1155/2015/313021
[Indexed for MEDLINE]
Free PMC Article

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