Send to

Choose Destination
Dev Reprod. 2012 Dec;16(4):235-51. doi: 10.12717/DR.2012.16.4.235.

The consequences of mutations in the reproductive endocrine system.

Author information

Dept. of Life Science, College of Environmental Sciences, Yong-In University, Yongin 449-714, Korea.


The reproductive activity in male mammals is well known to be regulated by the hypothalamus-pituitary- gonad axis. The hypothalamic neurons secreting gonadotropin releasing hormone (GnRH) govern the reproductive neuroendocrine system by integrating all the exogenous information impinging on themselves. The GnRH synthesized and released from the hypothalamus arrives at the anterior pituitary through the portal vessels, provoking the production of the gonadotropins(follicle-stimulating hormone (FSH) and luteinizing hormone (LH)) at the same time. The gonadotropins affect the gonads to promote spermatogenesis and to secret testosterone. Testosterone acts on the GnRH neurons by a feedback loop through the circulatory system, resulting in the balance of all the hormones by regulating reproductive activities. These hormones exert their effects by acting on their own receptors, which are included in the signal transduction pathways as well. Unexpected aberrants are arised during this course of action of each hormone. This review summarizes these abnormal phenomena, including various mutations of molecules and their actions related to the reproductive function.


Hypothalamus-pituitary-gonad axis; Mammal; Mutation; Reproduction

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center