Send to

Choose Destination
J Oral Maxillofac Pathol. 2014 Sep-Dec;18(3):390-7. doi: 10.4103/0973-029X.151324.

Diagnostic procedures for autoimmune vesiculobullous diseases: A review.

Author information

Department of Oral Pathology, Kalka Dental College and Hospital, Meerut, Uttar Pradesh, India.
Department of Oral Pathology, Seema Dental College and Hospital, Rishikesh, Uttarakhand, India.
Department of Oral Medicine & Radiology, Institute of Dental Sciences, Bhubaneswar, Odisha, India.


Oral soft tissues are affected by numerous pathologic conditions of variable etiology and hence their appropriate management relies on their accurate diagnosis. Clinical identification of intact vesicle and bulla in the oral cavity is really a challenge due to the regular irritation and the friable nature of oral mucosa. Rupture of these lesions leads to erosions or ulcerations on the surface, hence making the diagnosis of vesiculobullous (VB) lesions is even more difficult due to the fact that the differential diagnosis along with VB lesions will also include ulcerative, immunological-mediated diseases, and neoplasms and systemic diseases. Hence, knowledge of the clinical presentation of these disorders and the relevant diagnostic procedures is important not just for dermatologists, but also for general practitioners and dentists. In this article, the various procedures have been explained that can be used for the diagnostic purpose of VB lesions.


Bulla; Vesiculobullous; enzyme-linked immunosorbent assay; immunofluorescence; mucocutaneous; salt split; vesicle

Supplemental Content

Full text links

Icon for Medknow Publications and Media Pvt Ltd Icon for PubMed Central
Loading ...
Support Center