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J Virol. 2015 Jul;89(14):6974-7. doi: 10.1128/JVI.01918-14. Epub 2015 May 6.

MAVS Coordination of Antiviral Innate Immunity.

Author information

1
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
2
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA stacy.horner@duke.edu.

Abstract

RNA virus infection is sensed in the cytoplasm by the retinoic acid-inducible gene I (RIG-I)-like receptors. These proteins signal through the host adaptor protein MAVS to trigger the antiviral innate immune response. Here, we describe how MAVS subcellular localization impacts its function and the regulation underlying MAVS signaling. We propose a model to describe how the coordination of MAVS functions at the interface between the mitochondria and the mitochondrion-associated endoplasmic reticulum (ER) membrane programs antiviral signaling.

PMID:
25948741
PMCID:
PMC4473567
DOI:
10.1128/JVI.01918-14
[Indexed for MEDLINE]
Free PMC Article

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