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Cell Mol Life Sci. 2015 Aug;72(16):3083-96. doi: 10.1007/s00018-015-1917-z. Epub 2015 May 7.

Atg1 family kinases in autophagy initiation.

Author information

1
Institute of Microbial Chemistry (BIKAKEN), 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, 141-0021, Japan, nn@bikaken.or.jp.

Abstract

Autophagosome formation, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. Among all Atg proteins, Atg1 kinase in yeast and its counterpart in higher eukaryotes, ULK1 kinase, function as the most upstream factor in this process and mediate autophagy initiation. In this review, we summarize current knowledge of the structure, molecular function, and regulation of Atg1 family kinases in the initiation of autophagy.

PMID:
25948417
PMCID:
PMC4506457
DOI:
10.1007/s00018-015-1917-z
[Indexed for MEDLINE]
Free PMC Article

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