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PLoS One. 2015 May 6;10(5):e0126550. doi: 10.1371/journal.pone.0126550. eCollection 2015.

Espresso coffee consumption and risk of coronary heart disease in a large Italian cohort.

Author information

1
Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
2
Human Genetics Foundation, Turin, Italy; Unit of Cancer Epidemiology, University of Turin and Center for Cancer Prevention, Turin, Italy.
3
Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy.
4
Department of Clinical and Experimental Medicine, University of Naples Federico II, Naples, Italy.
5
Department of Medicine and Public Health, Second University of Naples, Naples, Italy.
6
Cancer Registry, Department of Prevention, Provincial Health Centre 7, Ragusa, Italy.
7
Laboratory of Molecular and Nutritional Epidemiology. Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo, Pozzilli, Italy.
8
Human Genetics Foundation, Turin, Italy; School of Public Health, Imperial College, London, United Kingdom.

Abstract

BACKGROUND:

The relationship between coffee consumption and coronary heart disease (CHD) has been investigated in several studies with discrepant results. We examined the association between Italian-style (espresso and mocha) coffee consumption and CHD risk.

METHODS:

We investigated 12,800 men and 30,449 women without history of cardiovascular disease recruited to the EPICOR prospective cohort study. Coffee consumption was assessed at baseline. In a random sub-cohort of 1472 subjects, plasma triglycerides, and total, LDL and HDL cholesterol were determined to investigate the effect of coffee consumption on plasma lipids.

RESULTS:

After a mean follow up of 10.9 years, 804 cases of CHD (500 acute events, 56 fatal events and 248 revascularizations, all first events) were identified. Multivariable adjusted hazard ratios for CHD were: 1.18 (95% CI 0.87-1.60) for drinking 1-2 cups/day, 1.37 (95% CI 1.03-1.82) for >2-4 cups/day and 1.52 (95% CI 1.11-2.07) for over 4 cups/day (P trend <0.001) compared to reference (<1 cup/day). Plasma triglycerides, and total, LDL and HDL cholesterol did not vary significantly (ANOVA) with coffee consumption.

CONCLUSION:

Consumption of over 2 cups/day of Italian-style coffee is associated with increased CHD risk, but coffee consumption was not associated with plasma lipid changes, so the adverse effect of consumption appears unrelated to lipid profile.

PMID:
25946046
PMCID:
PMC4422699
DOI:
10.1371/journal.pone.0126550
[Indexed for MEDLINE]
Free PMC Article

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