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World J Biol Psychiatry. 2015;16(8):635-9. doi: 10.3109/15622975.2015.1036115. Epub 2015 May 6.

Methylphenidate mediated change in prosody is specific to the performance of a cognitive task in female adult ADHD patients.

Bloch Y1,2,3, Aviram S1,4, Neeman R1,4, Braw Y1,5, Nitzan U1,3, Maoz H1,2,3, Mimouni-Bloch A1,3,6.

Author information

1
a The Emotion-Cognition Research Center, Shalvata Mental Health Care Center , Hod-Hasharon , Israel.
2
b Child and Adolescent Outpatient Clinic, Shalvata Mental Health Care Center , Hod-Hasharon , Israel.
3
c Sackler Faculty of Medicine, Tel-Aviv University , Tel-Aviv , Israel.
4
d Department of Psychology , Haifa University , Haifa , Israel.
5
e Department of Behavioral Sciences , Ariel University Center of Samaria , Ariel , Israel.
6
f The Pediatric Neurology and Developmental Unit, Loewenstein Rehabilitation Hospital , Raanana , Israel.

Abstract

OBJECTIVES:

Prosody production is highly personalized, related to both the emotional and cognitive state of the speaker and to the task being performed. Fundamental frequency (F main) is a central measurable feature of prosody, associated with having an attention deficit hyperactive disorder (ADHD). Since methylphenidate is an effective therapy for ADHD, we hypothesized that it will affect the fundamental frequency of ADHD patients.

METHODS:

The answers of 32 adult ADHD patients were recorded while performing two computerized tasks (cognitive and emotional). Evaluations were performed at baseline and an hour after patients received methylphenidate.

RESULTS:

A significant effect of methylphenidate was observed on the fundamental frequency, as opposed to other parameters, of prosody. This change was evident while patients performed a cognitive, as opposed to an emotional, task. This change was seen in the 14 female ADHD patients but not in the 18 male ADHD patients. The fundamental frequency while performing a cognitive task without methylphenidate was not different in the female ADHD group, from 22 female controls.

CONCLUSIONS:

This pilot study supports prosodic changes as possible objective and accessible dynamic biological marker of treatment responses specifically in female ADHD.

KEYWORDS:

ADHD; gender; main frequency; pharmacotherapy; prosody

PMID:
25945954
DOI:
10.3109/15622975.2015.1036115
[Indexed for MEDLINE]

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