Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Ind Med. 2015 Jun;58(6):625-35. doi: 10.1002/ajim.22462. Epub 2015 May 5.

Occupational exposures and risk of dementia-related mortality in the prospective Netherlands Cohort Study.

Author information

  • 1Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht.
  • 2Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht.
  • 3Occupational Respiratory Epidemiology, School of Population Health, University of Western Australia, Perth, Australia.
  • 4Julius Centre for Public Health Sciences and Primary Care, University Medical Center, Utrecht.

Abstract

BACKGROUND:

Occupational exposures may be associated with non-vascular dementia.

METHODS:

We analyzed the effects of occupational exposures to solvents, pesticides, metals, extremely low frequency magnetic fields (ELF-MF), electrical shocks, and diesel motor exhaust on non-vascular dementia related mortality in the Netherlands Cohort Study (NLCS). Exposures were assigned using job-exposure matrices. After 17.3 years of follow-up, 682 male and 870 female cases were available. Analyses were performed using Cox regression.

RESULTS:

Occupational exposure to metals, chlorinated solvents and ELF-MF showed positive associations with non-vascular dementia among men, which seemed driven by metals (hazard ratio ever high vs. background exposure: 1.35 [0.98-1.86]). Pesticide exposure showed statistically significant, inverse associations with non-vascular dementia among men. We found no associations for shocks, aromatic solvents, and diesel motor exhaust.

CONCLUSIONS:

Consistent positive associations were found between occupational exposure to metals and non-vascular dementia. The finding on pesticides is not supported in the overall literature.

KEYWORDS:

Alzheimer's disease; cohort; dementia; diesel motor exhaust; extremely low frequency magnetic fields; metals; occupation; pesticides; solvents

PMID:
25943788
DOI:
10.1002/ajim.22462
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center