Format

Send to

Choose Destination
See comment in PubMed Commons below
Mucosal Immunol. 2015 Jul;8(4):720-30. doi: 10.1038/mi.2015.40. Epub 2015 May 6.

Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease.

Author information

1
1] Genentech, South San Francisco, California, USA [2] Department of Pathology, The University of Chicago, Chicago, Illinois, USA.
2
Department of Pathology, The University of Chicago, Chicago, Illinois, USA.

Abstract

Compromised intestinal barrier function is a prominent feature of inflammatory bowel disease (IBD). However, links between intestinal barrier loss and disease extend much further, including documented associations with celiac disease, type I diabetes, rheumatoid arthritis, and multiple sclerosis. Intestinal barrier loss has also been proposed to have a critical role in the pathogenesis of graft-versus-host disease (GVHD), a serious, potentially fatal consequence of hematopoietic stem cell transplantation. Experimental evidence has begun to support this view, as barrier loss and its role in initiating and establishing a pathogenic inflammatory cycle in GVHD is emerging. Here we discuss similarities between IBD and GVHD, mechanisms of intestinal barrier loss in these diseases, and the crosstalk between barrier loss and the immune system, with a special focus on natural killer (NK) cells. Unanswered questions and future research directions on the topic are discussed along with implications for treatment.

PMID:
25943273
DOI:
10.1038/mi.2015.40
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center