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Curr Opin Cell Biol. 2015 Jun;34:23-30. doi: 10.1016/j.ceb.2015.04.003. Epub 2015 May 15.

Nuclear bodies: the emerging biophysics of nucleoplasmic phases.

Author information

1
Princeton University, Department of Chemical and Biological Engineering, Princeton, NJ 08544, USA.
2
Princeton University, Department of Chemical and Biological Engineering, Princeton, NJ 08544, USA. Electronic address: cbrangwy@princeton.edu.

Abstract

The cell nucleus contains a large number of membrane-less bodies that play important roles in the spatiotemporal regulation of gene expression. Recent work suggests that low complexity/disordered protein motifs and repetitive binding domains drive assembly of droplets of nuclear RNA/protein by promoting nucleoplasmic phase separation. Nucleation and maturation of these structures is regulated by, and may in turn affect, factors including post-translational modifications, protein concentration, transcriptional activity, and chromatin state. Here we present a concise review of these exciting recent advances, and discuss current and future challenges in understanding the assembly, regulation, and function of nuclear RNA/protein bodies.

PMID:
25942753
PMCID:
PMC5562147
DOI:
10.1016/j.ceb.2015.04.003
[Indexed for MEDLINE]
Free PMC Article

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