Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuroscience. 1989;31(3):697-709.

Two calcium-binding proteins mark many chick sensory neurons.

Author information

1
Physiological Laboratory, University of Cambridge, U.K.

Abstract

The first immunohistochemical results with a new neuronal calcium-binding protein, calretinin, are presented. Calretinin is related to the 28,000 mol. wt calcium-binding protein, calbindin, and a survey of the chick brain by in situ hybridization has identified the brain nuclei that expressed the genes for the two proteins [Rogers J.H., J. Cell Biol. 105, 1343 (1987)]. Now, antisera have been raised against calretinin fusion proteins in order to visualize individual neurons. The antisera have been used in an immunohistochemical survey of calretinin and calbindin in the chick sensory nuclei and ganglia, where these two proteins are found to be particularly prevalent. In the central nervous system, they are seen in many secondary sensory neurons and local circuit neurons, the two proteins being almost always in separate cells. However, in ganglion cells of the spinal nerves, inner ear, and retina, they are often expressed together. Their distribution in the brain is generally different from that of a third calcium-binding protein, parvalbumin. These proteins may modulate many important calcium-dependent processes in neurons, and probably have multiple functions.

PMID:
2594198
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center