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BMJ Open. 2015 May 3;5(4):e007736. doi: 10.1136/bmjopen-2015-007736.

Diagnosed diabetes and premature death among middle-aged Japanese: results from a large-scale population-based cohort study in Japan (JPHC study).

Author information

1
Department of Diabetes Research, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan Fiore Kenshin Clinic, Tokyo, Japan.
2
Department of Diabetes Research, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan.
3
Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.
4
Department of Diabetes Research, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan Department of Public Health, Tokyo Women's Medical University, Tokyo, Japan.
5
Division of Diabetes and Metabolism, Iwate Medical University School of Medicine, Morioka, Japan.
6
Department of Clinical Research, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.
7
Department of Public Health, Department of Social and Environmental Medicine, Osaka University, Graduate School of Medicine, Osaka-fu, Japan.
8
Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
9
Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.

Abstract

OBJECTIVE:

To examine the association between diabetes and premature death for Japanese general people.

DESIGN:

Prospective cohort study.

SETTING:

The Japan Public Health Center-based prospective study (JPHC study), data collected between 1990 and 2010.

POPULATION:

A total of 46,017 men and 53,567 women, aged 40-69 years at the beginning of baseline survey.

MAIN OUTCOME MEASURES:

Overall and cause specific mortality. Cox proportional hazards models were used to calculate the HRs of all cause and cause specific mortality associated with diabetes.

RESULTS:

The median follow-up period was 17.8 years. During the follow-up period, 8223 men and 4640 women have died. Diabetes was associated with increased risk of death (856 men and 345 women; HR 1.60, (95% CI 1.49 to 1.71) for men and 1.98 (95% CI 1.77 to 2.21) for women). As for the cause of death, diabetes was associated with increased risk of death by circulatory diseases (HR 1.76 (95% CI 1.53 to 2.02) for men and 2.49 (95% CI 2.06 to 3.01) for women) while its association with the risk of cancer death was moderate (HR 1.25 (95% CI 1.11 to 1.42) for men and 1.04 (95% CI 0.82 to 1.32) for women). Diabetes was also associated with increased risk of death for 'non-cancer, non-circulatory system disease' (HR 1.91 (95% CI 1.71 to 2.14) for men and 2.67 (95% CI 2.25 to 3.17) for women).

CONCLUSIONS:

Diabetes was associated with increased risk of death, especially the risk of death by circulatory diseases.

KEYWORDS:

DIABETES & ENDOCRINOLOGY; EPIDEMIOLOGY

PMID:
25941187
PMCID:
PMC4420968
DOI:
10.1136/bmjopen-2015-007736
[Indexed for MEDLINE]
Free PMC Article

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