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Cancer Sci. 2015 Jul;106(7):819-24. doi: 10.1111/cas.12688. Epub 2015 May 26.

MiR-940 inhibits hepatocellular carcinoma growth and correlates with prognosis of hepatocellular carcinoma patients.

Author information

1
Department of General Practice, West China Hospital, Sichuan University, Chengdu, China.

Abstract

Hepatocellular carcinoma (HCC) is among the leading causes of cancer-related death in China. Deregulation of microRNA (miRNA) contributes to HCC development by influencing cell growth, apoptosis, migration or invasion. It has been proved that miR-940 plays important roles in various cancers. Here we investigated the role of miR-940 in HCC. We found that miR-940 was remarkably decreased in HCC tissues and cell lines. Importantly, lower miR-940 expression in HCC tissues significantly correlated with the reduced patient's survival rate. Overexpression of miR-940 inhibited HCC cell line growth and induced cell apoptosis, and vice versa. Estrogen-related receptor gamma (ESRRG) was targeted by miR-940, and suppression of ESRRG inhibited HCC cell lines growth and induced cell apoptosis. In conclusion, we found that a lower level of miR-940 in HCC promoted cellular proliferation via ESRRG, which may lead to the short survival period of HCC patients.

KEYWORDS:

Cell proliferation; estrogen-related receptor gamma; hepatocellular carcinoma; miR-940; patients' survival

PMID:
25940592
PMCID:
PMC4520632
DOI:
10.1111/cas.12688
[Indexed for MEDLINE]
Free PMC Article

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