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Am J Ind Med. 2015 Jul;58(7):764-72. doi: 10.1002/ajim.22463. Epub 2015 May 5.

Biomarkers for polycyclic aromatic hydrocarbons and serum liver enzymes.

Author information

1
Department of Preventive Medicine, Dongguk University College of Medicine, Gyeongju-si, South Korea.
2
Department of Preventive Medicine, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju-si, South Korea.

Abstract

BACKGROUND:

Limited evidence suggests that human liver toxicity is associated with exposure to polycyclic aromatic hydrocarbons (PAHs).

METHODS:

The association of urinary PAH metabolites with serum liver enzymes was tested among 288 workers at a petrochemical plant, using a general linear model (GLM) and multiple logistic regression.

RESULTS:

Urine 2-naphthol levels were positively correlated with serum AST after adjustment for covariates in GLM. Comparing third tertile versus first tertile of 2-naphthol levels, the odds ratios (OR) were elevated for abnormal serum AST levels [OR = 4.1 (95%CI 1.6-10.2)] and abnormal serum ALT levels [OR = 2.4 (95%CI 1.2-4.9)].

CONCLUSIONS:

Although confounding by alcohol intake was not completely ruled out, our findings demonstrate an association between PAHs exposure and elevation in serum liver enzymes. Urinary 2-naphthol is a biomarker of exposure to PAHs that is associated with liver toxicity.

KEYWORDS:

2-naphthol; PAHs; biomarker; liver; polycyclic aromatic hydrocarbon; toxicity

PMID:
25940037
DOI:
10.1002/ajim.22463
[Indexed for MEDLINE]

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