Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Neurosci. 2015 Jun;38(6):353-63. doi: 10.1016/j.tins.2015.04.001. Epub 2015 May 1.

Congenital cardiac anomalies and white matter injury.

Author information

1
Center for Neuroscience Research and Children's National Heart Institute, Children's National Medical Center, Washington, DC 20010, USA.
2
Center for Neuroscience Research and Children's National Heart Institute, Children's National Medical Center, Washington, DC 20010, USA. Electronic address: vgallo@cnmc.org.

Abstract

Cardiac abnormalities are the most common birth defects. Derangement of circulatory flow affects many vital organs; without proper supply of oxygenated blood, the brain is particularly vulnerable. Although surgical interventions have greatly reduced mortality rates, patients often suffer an array of neurological deficits throughout life. Neuroimaging provides a macroscopic assessment of brain injury and has shown that white matter (WM) is at risk. Oligodendrocytes and myelinated axons have been identified as major targets of WM injury, but still little is known about how congenital heart anomalies affect the brain at the cellular level. Further integration of animal model studies and clinical research will define novel therapeutic targets and new standards of care to prevent developmental delay associated with cardiac abnormalities.

KEYWORDS:

glial cells; heart; myelin; neuroimaging; oligodendrocyte

PMID:
25939892
PMCID:
PMC4461528
DOI:
10.1016/j.tins.2015.04.001
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center