High-glucose-cultivated peripheral blood mononuclear cells impaired keratinocyte function via reduced IL-22 expression: implications on impaired diabetic wound healing

Exp Dermatol. 2015 Aug;24(8):639-41. doi: 10.1111/exd.12733.
No abstract available

Keywords: MMP-3; high glucose; interleukin-22; keratinocytes; mononuclear cells.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Cell Movement / drug effects
  • Culture Media, Conditioned / pharmacology
  • Diabetes Mellitus, Experimental / physiopathology
  • Glucose / pharmacology*
  • Humans
  • Interleukin-22
  • Interleukins / biosynthesis
  • Interleukins / genetics
  • Interleukins / physiology*
  • Keratinocytes / cytology
  • Keratinocytes / drug effects*
  • Leukocytes, Mononuclear / drug effects*
  • Leukocytes, Mononuclear / metabolism
  • Male
  • Matrix Metalloproteinase 3 / biosynthesis
  • Matrix Metalloproteinase 3 / genetics
  • Osmolar Concentration
  • RNA Interference
  • RNA, Messenger / biosynthesis
  • RNA, Messenger / genetics
  • Rats
  • Rats, Wistar
  • Receptors, Interleukin / physiology
  • Skin / injuries
  • Skin / metabolism
  • Wound Healing

Substances

  • Culture Media, Conditioned
  • IL22RA2 protein, human
  • Interleukins
  • RNA, Messenger
  • Receptors, Interleukin
  • Matrix Metalloproteinase 3
  • Glucose