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Metabolism. 1989 Dec;38(12):1162-3.

Hyperglycemia may determine fibrinopeptide A plasma level increase in humans.

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Cattedra di Diabetologia e Dietoterapia, I Facoltà di Medicina, Università di Napoli, Italy.


The effects of hyperglycemia on plasma fibrinopeptide A (FPA) levels in normal subjects are reported. An increase of FPA concentration parallel to sustained hyperglycemia was observed; when the glycemia returned to basal values, FPA showed values in normal range. Heparin infusion was able to significantly decrease the hyperglycemia-induced augment of FPA levels. Isovolumic-isotonic NaCl solution infusion produced a slight (NS) increase in FPA levels; however, mild hyperglycemia, achieved by glucagon, was also able to produce a significant increase in FPA concentration. These data demonstrate the direct role of hyperglycemia in conditioning FPA level, and suggest that hyperglycemia, by itself, is a sufficient stimulus to produce thrombin activation in humans.

[Indexed for MEDLINE]

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