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BMB Rep. 2015 Jul;48(7):419-25.

Oral administration of fermented wild ginseng ameliorates DSS-induced acute colitis by inhibiting NF-κB signaling and protects intestinal epithelial barrier.

Author information

1
Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 406-840, Korea.
2
Research Institute, National Cancer Center, Goyang 410-769, Korea.
3
College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.
4
Sempio Fermentation Research center, Osong 363-954, Korea.
5
Fermentation Research center, Osong 363-954, Korea.

Abstract

Ginseng has been widely used for therapeutic and preventive purposes for thousands of years. However, orally administered ginseng has very low bioavailability and absorption in the intestine. Therefore, fermented ginseng was developed to enhance the beneficial effects of ginseng in the intestine. In this study, we investigated the molecular mechanisms underlying the anti-inflammatory activity of fermented wild ginseng (FWG). We found that FWG significantly alleviated the severity of colitis in a dextran sodium sulfate (DSS)-induced colitis mouse model, and decreased expression level of pro-inflammatory cytokines in colonic tissue. Moreover, we observed that FWG suppressed the infiltration of macrophages in DSS-induced colitis. FWG also attenuated the transcriptional activity of nuclear factor-κB (NF-κB) by reducing the translocation of NF-κB into the nucleus. Our data indicate that FWG contains anti-inflammatory activity via NF-κB inactivation and could be useful for treating colitis.

PMID:
25936779
PMCID:
PMC4577293
[Indexed for MEDLINE]
Free PMC Article

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