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FEBS Lett. 2015 Jun 4;589(13):1485-90. doi: 10.1016/j.febslet.2015.04.037. Epub 2015 Apr 30.

MicroRNA-19a regulates proliferation and apoptosis of castration-resistant prostate cancer cells by targeting BTG1.

Author information

1
Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China. Electronic address: kai.5391@hotmail.com.
2
Department of Medicine, Southeast University, Nanjing, China.
3
Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
4
Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China; Department of Medicine, Southeast University, Nanjing, China.

Abstract

MicroRNAs (miRNAs) play a significant role in tumor development. Recent studies indicate that miRNAs are implicated in prostate cancer (PCa). In this study, we found that miR-19a expression was significantly increased in castration-resistant prostate cancer (CRPC) tissues compared with androgen-dependent prostate cancer (ADPC) tissues. We found that inhibiting the overexpression of miR-19a in CRPC cells suppressed proliferation and increased apoptosis. Additionally, we found that miR-19a repressed BTG1 expression by binding to its 3'-untranslated region. The overexpression of BTG1 in CRPC cells significantly suppressed proliferation and increased apoptosis. We conclude that miR-19a regulates proliferation and apoptosis of CRPC cells by directly targeting the tumor suppressor gene BTG1.

KEYWORDS:

Apoptosis; BTG1; MiR-19a; Proliferation; Prostate cancer

PMID:
25936765
DOI:
10.1016/j.febslet.2015.04.037
[Indexed for MEDLINE]
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