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Colloids Surf B Biointerfaces. 2015 Jun 1;130:278-86. doi: 10.1016/j.colsurfb.2015.04.026. Epub 2015 Apr 20.

Electrospinning polyvinylidene fluoride fibrous membranes containing anti-bacterial drugs used as wound dressing.

Author information

1
Institute of Biomaterial, Department of Applied Chemistry, College of Science, South China Agricultural University, Guangzhou 510642, China.
2
Research Center of Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
3
Department of Anatomy, Guangdong Provincial Key laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou 510515, China.
4
College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
5
Key Laboratory of Application Technology of Environmental Photocatalysis of Hunan Province, Changsha University, Changsha 410022, China.
6
Research Center of Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China. Electronic address: dengyub@mail.sysu.edu.cn.
7
Department of Anatomy, Guangdong Provincial Key laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou 510515, China. Electronic address: zhanghwu@mail2.sysu.edu.cn.
8
Institute of Biomaterial, Department of Applied Chemistry, College of Science, South China Agricultural University, Guangzhou 510642, China. Electronic address: zhouwuyi@scau.edu.cn.

Abstract

The aim of this study was to synthesis drug-loaded fibrous membrane scaffolds for potential applications as wound dressing. Polyvinylidene fluoride (PVDF) fibrous membranes were loaded with enrofloxacin (Enro) drugs by using an electrospinning process, and their mechanical strength, drug release profile and anti-bacterial properties were evaluated. Enro drug-loaded PVDF membranes exhibited good elasticity, flexibility and excellent mechanical strength. The electrospinning Enro/PVDF membranes showed a burst drug release in the initial 12h, followed by sustained release for the next 3 days, which was an essential property for antibiotic drugs applied for wound healing. The drug-loaded PVDF fibrous membranes displayed excellent anti-bacterial activity toward Escherichia coli and Staphylococcus aureus. The results suggest that electrospinning PVDF membrane scaffolds loaded with drugs can be used as wound dressing.

KEYWORDS:

Drug release; Electrospinning; Enro/PVDF fibrous membranes; Wound dressing

PMID:
25936562
DOI:
10.1016/j.colsurfb.2015.04.026
[Indexed for MEDLINE]

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