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Curr Opin Cell Biol. 2015 Jun;34:16-22. doi: 10.1016/j.ceb.2015.04.011. Epub 2015 May 15.

Role of chromatin, environmental changes and single cell heterogeneity in non-coding transcription and gene regulation.

Author information

1
Department of Cell Biology, iGE3, 30 Quai E. Ansermet, 1211 Geneva, Switzerland. Electronic address: manuele.castelnuovo@gmail.com.
2
Department of Cell Biology, iGE3, 30 Quai E. Ansermet, 1211 Geneva, Switzerland. Electronic address: Francoise.Stutz@unige.ch.

Abstract

The number and variety of factors underlying control of gene expression have been frequently underestimated. Non-coding RNAs generated through pervasive transcription have recently been implicated in shaping the transcriptional landscape in different organisms from bacteria to higher eukaryotes, adding a previously unexpected layer of complexity to the process of gene regulation. In this review, we highlight non-coding transcription-dependent regulatory mechanisms linked to chromatin organization and environmental changes, and particular emphasis is given to single-cell approaches, which have been crucial in dissecting cell-to-cell variability. These studies have revealed that non-coding transcription can underlie the extensive heterogeneity in patterns of gene expression within a cell population.

PMID:
25935760
DOI:
10.1016/j.ceb.2015.04.011
[Indexed for MEDLINE]

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