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Eur J Nutr. 2016 Apr;55(3):981-9. doi: 10.1007/s00394-015-0912-3. Epub 2015 May 3.

Association between n-3 polyunsaturated fatty acids in erythrocytes and metabolic syndrome in Chinese men and women.

Author information

1
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China.
2
Nanshan Maternal and Child Health Hospital of Shenzhen, Shenzhen, 518052, People's Republic of China.
3
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China. chenyum@mail.sysu.edu.cn.
4
Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China. chenyum@mail.sysu.edu.cn.
5
The Second Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, People's Republic of China.
6
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China. suyx@mail.sysu.edu.cn.
7
Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China. suyx@mail.sysu.edu.cn.

Abstract

PURPOSE:

Evidence of an association between n-3 polyunsaturated fatty acids (PUFAs) and metabolic syndrome (MS) is limited and inconsistent. We investigated the association between n-3 PUFAs in erythrocytes and the presence of MS in Chinese adults.

METHODS:

The levels of α-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) in erythrocytes were measured using gas chromatography in 3072 participants (900 men and 2172 women) aged 30-75 years from Guangzhou, China. Cardiometabolic factors were determined, and MS was defined using the updated Adult Treatment Panel III criteria. Other covariates were collected via interviewer-administered questionnaires.

RESULTS:

After adjusting for age and other confounders, higher levels of marine-derived n-3 PUFAs, including EPA, DPA, and DHA, were associated with a lower presence of metabolic syndrome in both men and women. The odds ratios (95 % confidence interval) for MS obtained by comparing extreme quartiles were 0.55 (0.35-0.88) (EPA), 0.54 (0.34-0.87) (DPA), 0.45 (0.27-0.73) (DHA), and 0.52 (0.32-0.84) (total n-3 PUFAs) in men (p trend <0.05 for all results); and 0.74 (0.56-0.99) (EPA), 0.73 (0.55-0.98) (DPA), 0.75 (0.56-1.02) (DHA), and 0.71 (0.53-0.96) (total n-3 PUFAs) in women, respectively. No significant association of ALA with MS was observed (p trend > 0.05).

CONCLUSION:

Higher levels of total n-3 PUFAs, EPA, DPA, and DHA, but not of ALA, in erythrocyte membranes are associated with a lower presence of metabolic syndrome in Chinese adults.

KEYWORDS:

Chinese adults; Erythrocyte; Metabolic syndrome; n-3 polyunsaturated fatty acids

PMID:
25935580
DOI:
10.1007/s00394-015-0912-3
[Indexed for MEDLINE]

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